Digital Pathophysiology Lab

We combine computational and biomedical techniques to study dynamic processes that evolve over time such as immune cell migration and progression of chronic diseases.
We are based at the Euler instiute, USI - Switzerland, where we promote contamination between researchers from different fields and support Open Science practices - see IMMUNEMAP project link -.
Competences: biomedical imaging, time-lapse microscopy of cell motility, bioimage analysis, computer vision, network theory, machine learning, trajectory mining, hardware prototyping, wearables and biosensors, amongst others.
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People

Diego Ulisse Pizzagalli
Diego Ulisse Pizzagalli
(Principal Investigator)

Diego is a researcher in computational medicine. After a PhD supported by SystemsX.ch - The Swiss Initiative in Systems Biology - in which he studied the behavior of immune cells in vivo, he translated trajectory analysis methods to other domains including wearables and disease dynamics. He is leading the lab since 2022 and he is co-directing the IMMUNEMAP project. He teaches subjects related to biomedical data analysis at USI and is editor at Frontiers in Immunology.

Raffaella Fiamma Cabini
Raffaella Fiamma Cabini
(Postdoc)

Raffaella obtained a PhD in Computational Mathematics and Decision Sciences at University of Pavia, which included a visiting period at USI. Her studies concern the design and implementation of algorithms and computational techniques for biomedical image processing and clinical data interpretation. Furthermore, she actively contributes to the dissemination and application of these techniques by participating in the organization of challenges that encourage the exploration of Open Science principles and aim to facilitate collaboration among researchers.

Mariaclaudia Nicolai
Mariaclaudia Nicolai
(Research Assistant)

Mariaclaudia has a pharmaceutical background with a strong interest in applying computational research methods. Her research focuses on using artificial intelligence (AI) by leveraging scientific discoveries in the laboratory and transforming them into new treatment approaches to improve healthcare. As a research assistant at the Università della Svizzera italiana, Mariaclaudia applies language models used in Natural Language Processing (NLP) that determine which word is more likely to appear next in the sentence to find machine learning-based solutions for microscopy data analysis for the IMMUNEMAP project.

Enrico Moscatello
Enrico Moscatello
(Software Engineer)

Enrico is a student of Engineering of Computing Systems at Politecnico di Milano. He is the main programmer and IT infrastructure manager for IMMUNEMAP, responsible for developing and maintaining the platform's robust functionalities. This involves creating intuitive user interfaces, implementing data storage and retrieval mechanisms, and ensuring the smooth functioning of the entire infrastructure.

Lala Chaimae Naciri
Lala Chaimae Naciri
(Visiting PhD Student)

Lala is a visiting PhD in Physiology from U. Cagliari. During her stay she will develop and apply machine learning methods for the analysis of fungiform papillae.

Lino Candian
Lino Candian
(Student Intern)

Lino is a student of Informatics at USI. During his research internship he is developing a novel sensor to transdermally image fluid accumulation in the abdomen. His work is supported by the UROP fellowship.

Selected works

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CompositIA
Automated computation of body composition scores from toraco-abdominal CT scans (upcoming)
Highly compatible
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Easy to customize
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Grow your business
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